Alison Hewson (née Stewart; born 23 March 1961) is an Irish activist and businesswoman. She is married to singer and musician Paul Hewson, known as Bono, from the rock group U2.

Raised in Raheny, she met her future husband at age 12 at Mount Temple Comprehensive School, and married him in 1982. She was awarded a degree in politics and sociology from University College Dublin (UCD) in 1989. The couple have four children together and live at residences in Ireland, France, and the United States. She has inspired several U2 songs, most famously "Sweetest Thing".

Hewson became involved in anti-nuclear activism in the 1990s. She narrated Black Wind, White Land, a 1993 Irish documentary about the lasting effects of the Chernobyl disaster, and has worked closely with activist Adi Roche. She has been a patron of Chernobyl Children's Project International since 1994 and has participated in a number of aid missions to the high-radiation exclusion zones of Belarus. She has also campaigned against Sellafield, the northern English nuclear facility. In 2002 she helped lead an effort which sent more than a million postcards, urging the site be closed, to Prime Minister Tony Blair and others. Hewson has repeatedly been discussed by tabloid newspapers as a possible candidate for political offices, including President of Ireland; none of these suggestions have come to fruition.

Hewson is the co-founder of two ethical businesses, the EDUN fashion line in 2005, and Nude Skincare products in 2007. The former, intended to promote fair trade with Africa, has struggled to become a viable business. French conglomerate LVMH has made substantial investments into both companies.